CA Top Secet r16 supports DB2 V11 out of the box.
CA Top Secret 15.0 does support DB2 V11 . You only need to apply the apar RO64641 to add new RDT entry for resource DB2VAR. This resource is needed for DB2 11.
The release of Top-Secret DB2 to support DB2 V11 is CA Top Secret DB2 Interface 1.3
You have information about the compatibility with different releases of DB2 in the following link:
Please note that the Component ENFDB2 of the CA Common Services also requires to be at the following level to support DB2 V11
CA Common Services for z/OS v14.0 plus PTF RO57084
CA Common Services for z/OS r14.1 plus PTF RO57094