This issue presents itself in the user interface with an error "An error has occurred on the server. Check the server log for details". Checking the c2o.log in Process Automation shows errors similar to this:
Caused by: com.mysql.jdbc.exceptions.jdbc4.MySQLSyntaxErrorException: Table 'PAM.C2ORuntimeObjectsarch' doesn't exist
Checking the database will show the table is there, but the case is different.