The error message CAPR421E INTERNAL ERROR CONDITION DETECTED. CONTACT CA. produced by load library allocated as PDSE.
The PDSE library requires BINDER option turn on to Analyzer process getting CAPR421E.
As the CA Optimizer/II install guide Appendix A stated for BINDER option as follow:
Specifies whether to access user load modules through the binder API function calls or the standard I/O macros. You must set this option to ON if the programs being analyzed reside in PDSE libraries.