CA APM .NET agent fails to run and show expected application metrics

Document ID : KB000115892
Last Modified Date : 05/11/2018
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After a successful CA APM .NET Agent install or manual deploy of .NET Agent No Installer files, the agent is failing to execute and show the expected application metrics.
APM 10.7
Windows 2012
In these images from the Process Explorer utility you can see that the w3wp process is successfully loading the wily.Agent assembly but it was using a different COR_PROFILER value than what was defined in the agent installation environment variables "{5F048FC6-251C-4684-8CCA-76047B02AC98}"

Process Explorer

User-added image

The root cause is the COR_PROFILER environmental variable is being hijacked by another application e.g. MS SCOM  (Microsoft System Center Operations Manager)
The w3wp process was attaching the COR_PROFILER of another CLR profiler from the application MS SCOM. We had to modify the registry to remove references to the MS SCOM app.
Additional Information:

Related KB articles:
Introscope .NET Agent Troubleshooting and Best Practices

How can we install the .NET Agent for 64-bit .NET Applications on Windows Server 2008 R2 by using NoInstaller files?