Check this setting on IE11 :
Tools -> Internet Options -> click Security tab. Your Security Zone level will be listed on this screen, by default this is set to Medium-high. To change the setting for your message click Custom Level , locate the Access data sources across domains under the Miscellaneous section , it has the following options :
1) With Disabled setting , you can see this problem ( i.e. "submit" button gets greyed out and you cannot do anything once you click "submit" button to submit a request .
2) With Prompt setting , you can see the security message prompt , click ok to continue , the request will get submitted successfully and it will work fine .
3) With Enable setting , you will not see any security message prompt and it works fine .